Tdy-negative XY, XXY and XYY female mice: breeding data and synaptonemal complex analysis
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چکیده
منابع مشابه
Normal structure and expression of Zfy genes in XY female mice mutant in Tdy.
Zfy-1 and Zfy-2 are candidate genes for Tdy, the testis-determining gene in mice. We have analysed these genes in a line of XY female mice that have been shown to be mutated in Tdy. We have used Southern blot analysis to show that the Zfy genes have not undergone any major structural alterations, and have also demonstrated that both genes are transcribed normally from the mutant Y chromosome (Y...
متن کاملXY follicle cells in the ovaries of XO/XY and XO/XY/XYY mosaic mice.
XO/XY and XO/XY/XYY mosaic hermaphrodites were generated from crosses involving BALB/cWt males. The distribution of Y-bearing cells in the gonads of these mice was studied by in situ hybridisation using the Y-specific probe pY353B. XY cells were found to contribute to all cell lineages of the ovary including follicle cells. The proportion of XY follicle cells was not significantly different fro...
متن کاملXY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy.
Chimeric mice constructed with XY embryonic stem (ES) cells that had been multiply infected with a retroviral vector were used in a genetic screen to look for mutations affecting the sex determination pathway in mice. From a small number of chimeras screened one was identified that gave rise to a low proportion of XY females amongst his offspring. Analysis of the segregating patterns of retrovi...
متن کاملMeiosis in Mice without a Synaptonemal Complex
The synaptonemal complex (SC) promotes fusion of the homologous chromosomes (synapsis) and crossover recombination events during meiosis. The SC displays an extensive structural conservation between species; however, a few organisms lack SC and execute meiotic process in a SC-independent manner. To clarify the SC function in mammals, we have generated a mutant mouse strain (Sycp1(-/-)Sycp3(-/-)...
متن کاملThe Mus musculus domesticus Tdy allele acts later than the Mus musculus musculus Tdy allele: a basis for XY sex-reversal in C57BL/6-Y mice
Consomic C57BL/6 males, carrying either the Mus musculus muscu/us-derived C57BL/6 Y chromosome or the Mus musculus domesticus-derived Poschiavinus Y chromosome, were outcrossed to females of the inbred strains C3H/Bi and CXBH/By and to females of the random bred strain MFl/Ola. In a study at 12.5 days post coitum, gonads of XY and XY fetuses were assessed for the presence of testicular cords. I...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1993
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0970151